
@article {84948,
	title = {Modulation of flight and feeding behaviours requires presynaptic IPRs in dopaminergic neurons.},
	journal = {Elife},
	volume = {9},
	year = {2020},
	month = {2020 Nov 06},
	abstract = {<p>Innate behaviours, although robust and hard wired, rely on modulation of neuronal circuits, for eliciting an appropriate response according to internal states and external cues. flight is one such innate behaviour that is modulated by intracellular calcium release through inositol 1,4,5-trisphosphate receptors (IPRs). Cellular mechanism(s) by which IPRs modulate neuronal function for specific behaviours remain speculative, in vertebrates and invertebrates. To address this, we generated an inducible dominant negative form of the IPR (IPR). Flies with neuronal expression of IPR exhibit flight deficits. Expression of IPR helped identify key flight-modulating dopaminergic neurons with axonal projections in the mushroom body. Flies with attenuated IPRs in these presynaptic dopaminergic neurons exhibit shortened flight bouts and a disinterest in seeking food, accompanied by reduced excitability and dopamine release upon cholinergic stimulation. Our findings suggest that the same neural circuit modulates the drive for food search and for undertaking longer flight bouts.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.62297},
	author = {Sharma, Anamika and Hasan, Gaiti}
}
