
@article {74445,
	title = {Global mistranslation increases cell survival under stress in Escherichia coli.},
	journal = {PLoS Genet},
	volume = {16},
	year = {2020},
	month = {2020 Mar 09},
	pages = {e1008654},
	abstract = {<p>Mistranslation is typically deleterious for cells, although specific mistranslated proteins can confer a short-term benefit in a particular environment. However, given its large overall cost, the prevalence of high global mistranslation rates remains puzzling. Altering basal mistranslation levels of Escherichia coli in several ways, we show that generalized mistranslation enhances early survival under DNA damage, by rapidly activating the SOS response. Mistranslating cells maintain larger populations after exposure to DNA damage, and thus have a higher probability of sampling critical beneficial mutations. Both basal and artificially increased mistranslation increase the number of cells that are phenotypically tolerant and genetically resistant under DNA damage; they also enhance survival at high temperature. In contrast, decreasing the normal basal mistranslation rate reduces cell survival. This wide-ranging stress resistance relies on Lon protease, which is revealed as a key effector that induces the SOS response in addition to alleviating proteotoxic stress. The new links between error-prone protein synthesis, DNA damage, and generalised stress resistance indicate surprising coordination between intracellular stress responses and suggest a novel hypothesis to explain high global mistranslation rates.</p>
},
	issn = {1553-7404},
	doi = {10.1371/journal.pgen.1008654},
	author = {Samhita, Laasya and Raval, Parth K and Agashe, Deepa}
}
