
@article {149370,
	title = {Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition.},
	journal = {Cell Rep},
	volume = {43},
	year = {2024},
	month = {2024 Sep 24},
	pages = {114654},
	abstract = {<p>Lower airway club cells (CCs) serve the dual roles of a secretory cell and a stem cell. Here, we probe how the\&nbsp;CC fate is regulated. We find that, in response to acute perturbation of Notch signaling, CCs adopt distinct fates. Although the vast majority transdifferentiate into multiciliated cells, a "variant" subpopulation (v-CCs), juxtaposed to neuroepithelial bodies (NEBs; 5\%-10\%) and located at bronchioalveolar duct junctions (\&gt;80\%), does not. Instead, v-CCs transition into lineage-ambiguous states but can revert to a CC fate upon restoration of Notch signaling and repopulate the airways with CCs and multiciliated cells. The v-CC response to Notch inhibition is dependent on localized activation of β-catenin in v-CCs. We propose that the CC fate is stabilized by canonical Notch signaling, that airways are susceptible to perturbations to this pathway, and that NEBs/terminal bronchioles comprise niches that modulate CC plasticity via β-catenin activation to facilitate airway repair post Notch inhibition.</p>
},
	keywords = {Animals, beta Catenin, Bronchioles, Mice, Mice, Inbred C57BL, Neuroepithelial Bodies, Receptors, Notch, Signal Transduction},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2024.114654},
	author = {Lingamallu, Sai Manoz and Deshpande, Aditya and Joy, Neenu and Ganeshan, Kirthana and Ray, Neelanjana and Ladher, Rajesh Kumar and Taketo, Makoto Mark and Lafkas, Daniel and Guha, Arjun}
}
