
@article {140641,
	title = {Fission yeast spindle dynamics and chromosome segregation fidelity show distinct thermosensitivity.},
	journal = {MicroPubl Biol},
	volume = {2024},
	year = {2024},
	month = {2024},
	abstract = {<p>Cellular processes rely on proteins with temperature-dependent stability and activity. While thermosensitivity in biological networks is well-explored, the effect of temperature on complex mechanochemical assemblies, like the spindle, is rarely studied. We examined fission yeast spindle dynamics and chromosome segregation from 15$^{0}$C to 40$^{0}$C. Our findings reveal that these parameters follow U-shaped temperature-dependent curves but reach their minima at different temperatures. Specifically, spindle dynamics peak around 35$^{0}$C, whereas chromosome segregation defects are minimized at 25$^{0}$C. This suggests a scenario in which mitotic errors are tolerated to expedite rapid cell cycle progression.</p>
},
	issn = {2578-9430},
	doi = {10.17912/micropub.biology.001048},
	author = {Chaba, Zachary and Jain, Ishutesh and Tran, Phong T}
}
