
@article {131935,
	title = {Prolongation of mitosis is associated with enhanced endogenous DNA damage in fission yeast.},
	journal = {MicroPubl Biol},
	volume = {2023},
	year = {2023},
	month = {2023},
	abstract = {<p>Mitosis is usually shorter than other phases of the cell cycle and maintains a consistent duration despite variations in cell size and spindle size. This suggests the existence of a compensatory mechanism that ensures a short duration, possibly as a protective measure against irreversible damage, such as DNA damage. To explore the link between prolonged mitosis and DNA damage, we develop a microscopy-based assay utilizing Rad52-GFP as a marker for mitotic DNA damage. Through this assay, we provide evidence that mutants with prolonged mitosis exhibit increased Rad52 puncta, indicating an elevation in endogenous DNA damage.</p>
},
	issn = {2578-9430},
	doi = {10.17912/micropub.biology.000911},
	author = {Jain, Ishutesh and Tran, Phong T}
}
