
@article {107012,
	title = {Store-operated Ca2+ entry regulates neuronal gene expression and function.},
	journal = {Curr Opin Neurobiol},
	volume = {73},
	year = {2022},
	month = {02/2022},
	pages = {102520},
	abstract = {<p>Recent studies with mutants of STIM and Orai have identified store-operated Ca<sup>2+</sup> entry as an important regulator of neuronal function in Drosophila and mouse. Cellular Ca<sup>2+</sup> imaging and electrophysiological studies demonstrate changes in ion channel function in neurons with loss of store-operated Ca<sup>2+</sup> entry. Importantly, such changes are specific to neuronal subtypes. Transcriptomic and single-cell gene expression studies from the mouse brain identified wide, and isoform-specific differences, in expression of genes required for ER-store Ca<sup>2+</sup> release and store-operated Ca<sup>2+</sup> entry, across different neuronal classes. Loss of store-operated Ca<sup>2+</sup> entry in neurons impacts neuronal gene expression profiles and includes genes encoding ion channels. The functional significance of store-operated Ca<sup>2+</sup> entry across specific neuronal subtypes and in the context of neurodegenerative syndromes needs further study.</p>
},
	doi = {10.1016/j.conb.2022.01.005},
	author = {Mitra, Rishav and Hasan, Gaiti}
}
