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Cellular Organisation and Signalling

A P U R V A    S A R I N

Laboratory Publications

  1. Garg M, Ramdas N, Vijayalakshmi M, Shivashankar GV, Sarin A
    The C-terminal domain (CTD) in linker histones antagonizes anti-apoptotic proteins to modulate apoptotic outcomes at the mitochondrion

    Cell Death Disease
    2014, 13;5:e1058. doi: 10/1038/cddis

  1. Garg M, Perumalsamy LR, Shivashankar GV, Sarin A
    The linker histone H1.2 is an intermediate in the apoptotic response to cytokine deprivation in T-effectors
    Int. J. Cell Biol
    . 2014, 2014:674753. doi: 10.1155/2014/674753.

  1. Purushothaman D*, Marcel N*, Garg M*, Venkataraman R, Sarin A
    Apoptotic programs are determined during lineage commitment of CD4+ T-effectors: Selective regulation of T-effector-memory apoptosis by iNOS
    J. Immunol
    . 2013, 190 (1): 97-105. *equal contribution

  1. Perumalsamy LR, Marcel N, Kulkarni K, Radtke F, Sarin A
    Distinct spatial and molecular features of Notch pathway assembly in Regulatory T-cells

    Science Signaling
    2012, 5 (234): ra53

  1. Gupta S*, Marcel N*, Sarin A, Shivashankar GV
    Role of actin dependent nuclear deformation in regulating early gene expression

    PLOS One, 2012, 7(12):e53031, *equal contribution

  1. Gupta S*, Marcel N*, Talwar S*, Garg M, Indulaxmi R, Perumalsamy L, Sarin A, Shivashankar GV
    Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration

    PLOS One
    , 2012 10.1371/journal.pone.0043718 *equal contribution.

  1. Perumalsamy LR, Nagala, M, Sarin A
    A Notch activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival

    Proc. Natl Acad Sci USA.
    2010, 107:6882-6887. [Epub 2010 Mar 25]

  1. Purushothanam D, Sarin A
    Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis

    J. Exp. Med.
    2009, 206:1515-23

  1. Perumalsamy LR, Nagala M, Bannerjee P, Sarin A
    A hierarchical cascade activated by non-canonical Notch signaling and the mTOR - Rictor complex regulates neglect-induced death in mammalian cells

    Cell Death & Differentiation
    2009, 16:879-889 [doi: 10.1038/cdd.2009.20]

  1. Srivastava S, Banerjee H, Chaudhry A, Khare A, Sarin A, George A, Bal V, Durdik JM, Rath S.
    Apoptosis-inducing factor (Aif) regulates death in peripheral T cells

    J. Immunol
    . 2007, 179: 797-803.

  1. Rao J, Bhattacharya D, Banerjee B, Sarin A, Shivashankar GV.
    Trichostatin-A induces differential changes in histone dynamics and expression in HeLa cells

    , 2007, 363:263-8.

  1. Parikh N, Koshy C, Dhayabharan V, Perumalsamy LR, Sowdhamini R, Sarin A.
    The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-x
    BMC Cell Biology
    . 2007 8:16.

  1. Goyal G, Fell B, Sarin A, Youle RJ, Sriram V.
    Role of mitochondrial remodeling in programmed cell death in
    Drosophila melanogaster Dev. Cell 2007, 12(5):807-16.

  1. Geetha B*, Divya P*, Sade H, Gunasekharan V, Rangarajan A, Sarin A.
    Evidence for a role for Notch signaling in the cytokine-dependent survival of activated T-cells

    J. Immunol
    . 177: 2007, 5041-5050. *equal contribution

  1. Parikh N, Sade H, Kurian L, Sarin A.
    The Bax amino-terminus is required for negative regulation by the MEK and Akt signaling pathways in T cells

    J. Immunol
    . 2004, 173:6220-6227.

  1. Vig M, Srivastava S, Kandpal U, Sade H, Lewis V, Sarin A, George A, Bal V, Durdik JM, Rath S. Inducible nitric oxide synthase in T cells regulates T cell death and immune memory
    J. Clin. Invest.
    2004, 113:1734-42.

  1. Sade H, Sarin A.
    Reactive oxygen species regulate quiescent T cell apoptosis via the BH3-only pro-apoptotic protein BIM

    Cell Death and Differentiation 2004,
    11: 416-423.

  1. Sade H, Khandre NS, Mathew MK, Sarin A.
    The mitochondrial phase of the glucocorticoid-induced apoptotic response in thymocytes comprises sequential activation of ANT-independent and ANT-dependent events

    Eur. J. Immunol.
    2004, 34:119-125.

  1. Sen A, Kuruvilla D, Pinto L, Sarin, Rodrigues V.
    Programmed cell death and context dependent activation of the EGF pathway regulate gliogenesis in the
    Drosophila olfactory system
    Mechanisms of Development 2004,
    121: 65-78.

  1. Sade H, Krishna S, Sarin A.
    The anti-apoptotic effect of Notch-1 requires p56
    lck-dependent, Akt/PKB-mediated signalling in T cells.
    J. Biol. Chem
    . 2004, 279(4): 2937-2944.

  1. Godbole A, Varghese J, Sarin A, Mathew MK
    VDAC is a conserved element of death pathways in plant and animal systems

    . 2004, 1642:87-96.

  1. Varghese J*, Khandre N*, Sarin A.
    Caspase-3 activation is an early event and initiates apoptotic damage in a human leukemia cell line

    2003, 8:363-370. *equal contribution

  1. Sade H, Sarin, A.
    Interleukin-7 blocks caspase-independent apoptosis in mature T cells via phosphatidylinositol-3 kinase (PI-3K)-mediated survival signalling

    Eur. J. Immunol. 2003,
    33: 913-919.

  1. Varghese J, Sade H, Vandenabeele P, Sarin A.
    Head involution defective (Hid) triggered apoptosis requires caspase-8 but not FADD (Fas associated death domain) and is regulated by the extracellular signal-related kianse-I/2 (Erk) in mammalian cells

    J. Biol. Chem.
    2002, 277(38): 35097-104.

  1. Varghese J, Radhika G, Sarin A
    The role of calpain in caspase activation during etoposide induced apoptosis in T cells

    Eur. J. Immunol
    . 2001, 31: 2035-2041.

  1. Varghese J, Chattopadhyay S, Sarin A.
    Inhibition of p38 kinase reveals a Tumour Necrosis Factor alpha (TNF) - mediated, caspase-dependent, apoptotic death pathway in a human myelomonocyte cell line

    J. Immunol
    . 2001 166:6570-6577