Recent Publications

• Gupta, A, Sarah Toscano, S, Trivedi, D, Jones DJ, Mathre S, Clarke J, Georgiev P, Divecha N and Raghu P. (2013) Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signalling and cell growth during Drosophila development.(Proc.Natl.Acad.Sci.USA published ahead of print March 25, 2013, doi:10.1073/pnas.1219333110).

• Chu B, Liu CH, Sengupta S, Gupta A, Raghu P, Hardie RC. (2013) Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors. J Neurophysiol. 2013 Jan 30. [Epub ahead of print].

•  Badsha F, Kain P, Prabhakar S, Sundaram S, Raghu P, Rodrigues V, Hasan G. (2012) Mutants in Drosophila TRPC Channels Reduce Olfactory Sensitivity to Carbon Dioxide. PLoS One. 2012; 7(11): e49848.

• Garner K, Hunt AN, Koster G, Somerharju P, Groves E, Li M, Raghu P, Holic R, Cockcroft S. (2012) Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers Phosphatidic Acid. J.Biol.Chem. Sep 14; 287(38): 32263-7.

• Georgiev P, Toscano S, Nair A, Hardie R, Raghu P. (2012) Identification of a suppressor of retinal degeneration in Drosophila photoreceptors. J. Neurogenet. Sep 26 (3-4): 338-47.

• Raghu, P., Yadav, S and Mallampati, N. (2012) Lipid signalling in Drosophila photoreceptors. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. Vesicular Transport. 1821(8):1154-65.

• Subramanian, M., Metya, S.K., Sadaf, S., Kumar, S., Schwudke, D. And Hasan, G. (2013). Altered lipid homeostasis in Drosophila InsP_3 receptor mutants leads to obesity and hyperphagia. /Dis. Model. Mech/ *6* doi: 10.1242/dmm.010017.

• Subramanian, M., Jayakumar, S., Richhariya, S and Hasan, G. (2013). Loss of IP_3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila. /BMC Neuroscience/ *14*:157-164.

• Kumar, S., Dey, D and Hasan, G. (2011) Patterns of gene expression in /Drosophila/ InsP_3 receptor mutant larvae reveal a role for InsP_3 signaling in carbohydrate and energy metabolism. /PLoS One, /*6(8)*:**e24105. doi:10.1371/journal.pone.0024105.

• Saha R, Verma PK, Rakshit S, Saha S, Mayor S, Pal SK. Light driven ultrafast electron transfer in oxidative redding of Green Fluorescent Proteins. Sci Rep.2013 Apr 3;3:1580

• Pols MS, van Meel E, Oorschot V, Ten Brink C, Fukuda M, Swetha MG, Mayor S, Klumperman J. (2013) hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins. Nat Commun. 2013 Jan 15;4:1361

• Gowrishankar K, Ghosh S, Saha S, C R, Mayor S, Rao M. (2012) Active remodeling of cortical actin regulates spatiotemporal organization of cell surface molecules, Cell.149(6):1353-67. (Also See:  Ivo F. Sbalzarini, Active Flows Cluster Cell Surface Proteins, Developmental Cell, 22, 1121-1122 (2012).

• Chaudhuri A, Bhattacharya B, Gowrishankar K, Mayor S, Rao M. (2011) Spatiotemporal regulation of chemical reactions by active cytoskeletal remodeling, Proc Natl Acad Sci U S A.108(36):14825-30.

• Swetha MG, Sriram V, Krishnan KS, Oorschot VM, ten Brink C, Klumperman J, Mayor S. (2011) Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells. Traffic.12(8):1037-55.

• Unique, Polyfucosylated Glycan–Receptor Interactions Are Essential for Regeneration of Hydra magnipapillata S Sahadevan, A Antonopoulos, SM Haslam, A Dell, S Ramaswamy, P Babu ACS chemical biology

• Ubiquitin Regulates Caspase Recruitment Domain-mediated Signaling by Nucleotide-binding Oligomerization Domain-containing Proteins NOD1 and NOD2 AM Ver Heul, CA Fowler, S Ramaswamy, RC Piper Journal of Biological Chemistry 288 (10), 6890-6902

• Atomic-Resolution Structures of Horse Liver Alcohol Dehydrogenase with NAD+ and Fluoroalcohols Define Strained Michaelis Complexes BV Plapp, S Ramaswamy Biochemistry 51 (19), 4035-4048

• One atom makes all the difference S Ramaswamy, Science 334 (6058), 914-915  2011.

• Integration of chemical and RNAi multiparametric profiles identifies triggers of intracellular mycobacterial killing. Sundaramurthy V, Barsacchi R, Samusik N, Marsico G, Gilleron J, Kalaidzidis I, Meyenhofer F, Bickle M, Kalaidzidis Y, Zerial M.Cell Host Microbe. 2013 Feb 13;13(2):129-42. doi: 10.1016/j.chom.2013.01.008.

• Rab5 is necessary for the biogenesis of the endolysosomal system in vivo. Zeigerer A, Gilleron J, Bogorad RL, Marsico G, Nonaka H, Seifert S, Epstein-Barash H, Kuchimanchi S, Peng CG, Ruda VM, Del Conte-Zerial P, Hengstler JG, Kalaidzidis Y, Koteliansky V, Zerial M. Nature. 2012 May 23;485(7399):465-70. doi: 10.1038/nature11133.

• Systems survey of endocytosis by multiparametric image analysis. Collinet C, Stöter M, Bradshaw CR, Samusik N, Rink JC, Kenski D, Habermann B, Buchholz F, Henschel R, Mueller MS, Nagel WE, Fava E, Kalaidzidis Y, Zerial M. Nature. 2010 Mar 11;464(7286):243-9. doi: 10.1038/nature08779. Epub 2010 Feb 28.

• Lipoproteins and Hedgehog signalling--possible implications for the adrenal gland function. Swierczynska MM, Lamounier-Zepter V, Bornstein SR, Eaton S. Eur J Clin Invest. 2013 Nov;43(11):1178-83. doi: 10.1111/eci.12145. Epub 2013 Sep 2.

• Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. Palm W, Swierczynska MM, Kumari V, Ehrhart-Bornstein M, Bornstein SR, Eaton S. PLoS Biol. 2013;11(3):e1001505. doi: 10.1371/journal.pbio.1001505. Epub 2013 Mar 12.

• Effects of diet and development on the Drosophila lipidome. Carvalho M, Sampaio JL, Palm W, Brankatschk M, Eaton S, Shevchenko A. Mol Syst Biol. 2012;8:600. doi: 10.1038/msb.2012.29.

• Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid composition. Palm W, Sampaio JL, Brankatschk M, Carvalho M, Mahmoud A, Shevchenko A, Eaton S. PLoS Genet. 2012;8(7):e1002828. doi: 10.1371/journal.pgen.1002828. Epub 2012 Jul 26.

• Patched regulates Smoothened trafficking using lipoprotein-derived lipids. Khaliullina H, Panáková D, Eugster C, Riedel F, Carvalho M, Eaton S. Development. 2009 Dec;136(24):4111-21. doi: 10.1242/dev.041392. Epub 2009 Nov 11.

• Crumbs regulates rhodopsin transport by interacting with and stabilizing myosin V. Pocha SM, Shevchenko A, Knust E. J Cell Biol. 2011 Nov 28;195(5):827-38. doi: 10.1083/jcb.201105144. Epub 2011 Nov 21.

• Increased levels of the cytoplasmic domain of Crumbs repolarise developing Drosophila photoreceptors. Muschalik N, Knust E. J Cell Sci. 2011 Nov 1;124(Pt 21):3715-25. doi: 10.1242/jcs.091223. Epub 2011 Oct 24.

• Retromer controls epithelial cell polarity by trafficking the apical determinant Crumbs. Pocha SM, Wassmer T, Niehage C, Hoflack B, Knust E. Curr Biol. 2011 Jul 12;21(13):1111-7. doi: 10.1016/j.cub.2011.05.007. Epub 2011 Jun 23.

• Crumbs affects protein dynamics in anterior regions of the developing Drosophila embryo. Firmino J, Tinevez JY, Knust E. PLoS One. 2013;8(3):e58839. doi: 10.1371/journal.pone.0058839. Epub 2013 Mar 21.

• Survival strategies of a sterol auxotroph. Carvalho M, Schwudke D, Sampaio JL, Palm W, Riezman I, Dey G, Gupta GD, Mayor S, Riezman H, Shevchenko A, Kurzchalia TV, Eaton S. Development. 2010 Nov;137(21):3675-85. doi: 10.1242/dev.044560.

• Long-chain O-ascarosyl-alkanediols are constitutive components of Caenorhabditis elegans but do not induce dauer larva formation. Zagoriy V, Matyash V, Kurzchalia T. Chem Biodivers. 2010 Aug;7(8):2016-22. doi: 10.1002/cbdv.201000012.

• Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology. Martin R, Entchev EV, Kurzchalia TV, Knölker HJ. Org Biomol Chem. 2010 Feb 21;8(4):739-50. doi: 10.1039/b918488k. Epub 2009 Dec 3.

• Maradolipids: diacyltrehalose glycolipids specific to dauer larva in Caenorhabditis elegans. Penkov S, Mende F, Zagoriy V, Erkut C, Martin R, Pässler U, Schuhmann K, Schwudke D, Gruner M, Mäntler J, Reichert-Müller T, Shevchenko A, Knölker HJ, Kurzchalia TV. Angew Chem Int Ed Engl. 2010 Dec 3;49(49):9430-5. doi: 10.1002/anie.201004466. No abstract available.

• Molecular Strategies of the Caenorhabditis elegans Dauer Larva to Survive Extreme Desiccation. Erkut /ScientificAdvisorsC, Vasilj A, Boland S, Habermann B, Shevchenko A, Kurzchalia TV. PLoS One. 2013 Dec 4;8(12):e82473. doi: 10.1371/journal.pone.0082473.

• Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes. Graessler J, Bornstein TD, Goel D, Bhalla VP, Lohmann T, Wolf T, Koch M, Qin Y, Licinio J, Wong ML, Chavakis T, Xu A, Shevchenko A, Schuhmann K, Schwarz PE, Schulte KM, Patel A, Bornstein SR.Pharmacogenomics J. 2013 Dec 24. doi: 10.1038/tpj.2013.42. [Epub ahead of print]

• Girard derivatization for LC-MS/MS profiling of endogenous ecdysteroids in Drosophila. Lavrynenko O, Nedielkov R, Möller HM, Shevchenko A. J Lipid Res. 2013 Aug;54(8):2265-72. doi: 10.1194/jlr.D035949. Epub 2013 Feb 19.

• A Global In Vivo Drosophila RNAi Screen Identifies a Key Role of Ceramide Phosphoethanolamine for Glial Ensheathment of Axons. Ghosh A, Kling T, Snaidero N, Sampaio JL, Shevchenko A, Gras H, Geurten B, Göpfert MC, Schulz JB, Voigt A, Simons M. PLoS Genet. 2013 Dec;9(12):e1003980. doi: 10.1371/journal.pgen.1003980. Epub 2013 Dec 12.

• Plasma lipid composition and risk of developing cardiovascular disease. Fernandez C, Sandin M, Sampaio JL, Almgren P, Narkiewicz K, Hoffmann M, Hedner T, Wahlstrand B, Simons K, Shevchenko A, James P, Melander O. PLoS One. 2013 Aug 15;8(8):e71846. doi: 10.1371/journal.pone.0071846. eCollection 2013.

• Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid composition. Palm W, Sampaio JL, Brankatschk M, Carvalho M, Mahmoud A, Shevchenko A, Eaton S. PLoS Genet. 2012;8(7):e1002828. doi: 10.1371/journal.pgen.1002828. Epub 2012 Jul 26.

• Shotgun lipidomics on a LTQ Orbitrap mass spectrometer by successive switching between acquisition polarity modes. Schuhmann K, Almeida R, Baumert M, Herzog R, Bornstein SR, Shevchenko A. J Mass Spectrom. 2012 Jan;47(1):96-104. doi: 10.1002/jms.2031.

• LipidXplorer: a software for consensual cross-platform lipidomics. Herzog R, Schuhmann K, Schwudke D, Sampaio JL, Bornstein SR, Schroeder M, Shevchenko A. PLoS One. 2012;7(1):e29851. doi: 10.1371/journal.pone.0029851. Epub 2012 Jan 17.

• Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane. Gerl MJ, Sampaio JL, Urban S, Kalvodova L, Verbavatz JM, Binnington B, Lindemann D, Lingwood CA, Shevchenko A, Schroeder C, Simons K. J Cell Biol. 2012 Jan 23;196(2):213-21. doi: 10.1083/jcb.201108175. Epub 2012 Jan 16.