A large number of signaling pathways were modeled in this project. In order to get more details about the reactions modeled for a specific signaling component, please click on the icon in this block diagram. This will select the corresponding detailed reaction scheme in the lower right (Reactions) panel, which corresponds to Figure 1 of the paper.
In order to look up the kinetic parameters used in each reaction, please click on the identifying number next to each reaction in the lower right (Reactions) panel. This will bring up the appropriate section of the table in the lower left (Simulation Parameters) panel.
Initial concentrations for primary reactants may be found by clicking on the reactant label in the Reactions panel. These are the only concentrations obtained from experimental sources, as the rest are computed by the simulation, and are not tabulated here. Concentrations of stimulus inputs (Glu and EGF) are described in the paper.
This page uses HTML4 frames. Netscape version 3.01 and later, and Microsoft Internet Explorer version 4 support this fully. Older versions of Internet Explorer will create separate windows while looking up reactions and rates, but the functionality will remain the same.
