PhD in Organic and Bio-organic chemistry
Siddan Gouthaman is a Research Assistant in our group and associated with Dr. Sanjukta Mukherjee’s project. He has received his doctoral degree from CSIR-Central Leather Research Institute, Chennai. During his Ph.D. studies, he acquired professional experience in the field of catalysis, medicinal chemistry, morphology, and topology, using various spectroscopic methods and imaging techniques to classify unexpected products and new materials.
gouthamans at ncbs dot res dot in
Development of novel DNA/RNA binding fluorescence chemical probe
Long wavelength probes would enable comprehensive imaging to reduce imaging noise and allow deep tissue imaging. Currently, my focus is development of novel fluorescence chemical probe incorporating chromophore that has emission maxima at longer wavelength to the general scaffold of cyclic mismatch binding ligands (CMBLs) to target biologically important DNA/RNA structure. Further to understand regulatory cellular mechanisms of targeted DNA/RNA that provide vital information for improving disease prevention and human health. To address this, we use interdisciplinary approaches of new and versatile scaffolds to enhance fluorescent biosensors for the subcellular compartment and live-cell imaging to the signaling dynamics. Notably, these will aid in the development of diagnostics and therapeutics targeting diseases such as cancer, neurodegenerative, and neuromuscular disorders that are currently incurable. We believe that would significantly broaden the repertoire of probes are using multiple imaging modalities for different sensitivity and specific targets.