Roadmap for Condensates in Cell Biology
| Title | Roadmap for Condensates in Cell Biology |
| Publication Type | Journal Article |
| Year of Publication | 2026 |
| Authors | Aierken D, Aland S, Bo S, Boeynaems S, Cai D, Carra S, Case LB, Chan HSun, Espinosa JR, GrandPre TK, Grosberg AY, Haugerud IS, Jacobs WM, Joseph JA, Jülicher F, Kremer K, Kusters G, Laan L, Lasker K, Laxhuber KS, Lee HO, Liu KF, Notani D, Qiang Y, Robustelli P, Saiz L, Saleh OA, Schiessel H, Schmit JD, Shen M, Shrinivas K, Statt A, Tejedor AR, Trcek T, Weber CA, Weber SC, Wingreen NS, Zhang H, Zhang Y, Zhou H-X, Zwicker D |
| Journal | PRX Life |
| Volume | 4 |
| Pagination | 032501 |
| Date Published | Aug |
| Abstract | Biomolecular condensates govern essential cellular processes yet elude description by traditional equilibrium models. This roadmap, distilled from structured discussions at a workshop and reflecting the consensus of its participants, clarifies key concepts for researchers, funding bodies, and journals. After unifying terminology that often separates disciplines, we outline the core physics of condensate formation, review their biological roles, and identify outstanding challenges in nonequilibrium theory, multiscale simulation, and quantitative in-cell measurements. We close with a forward-looking outlook to guide coordinated efforts toward predictive, experimentally anchored understanding and control of biomolecular condensates. |
| URL | https://link.aps.org/doi/10.1103/3b2k-ftwx |
| DOI | 10.1103/3b2k-ftwx |